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Casa Ybel Resort
2255 W Gulf Dr
Sanibel Island
Florida  US






Day 1: Thursday February 11, 2010

Introductory Remarks 08:30-08:40
Ivan Osorio (University of Kansas, Kansas City, KS, USA)


I. NFLE: Electroclinical, molecular and genetic aspects, macro and microscopic phenomenology

Gross and microscopic anatomy of the frontal lobe: Functional implications (08:40-09:40)
Speaker: Taufik Valiante (Toronto Western Hospital, Toronto, Canada)

Familial and sporadic NFLE: Electro-clinical features (09:40-10:40)
Speaker: Ronald Lesser (Johns Hopkins University, Baltimore, MD, USA)

Break 10:40-11:00

Nocturnal frontal lobe epilepsy: Is it frontal in origin? (11:00-noon)
Speaker: Patrick Chauvel (UMR Inserm U751 and Aix-Marseille Université, Marseille, France)

Lunch (noon-13:00)

Familial nocturnal frontal lobe epilepsy: Genetic and molecular aspects (13:00-14:00)
Speaker: Ortrud Steinlein (Ludwig-Maximilians-Universität, München, Germany)


II. NFLE: Mechanisms

Ion channels and epilepsy (14:00-15:00)
Speaker: Frank Lehmann-Horn (Ulm University, Ulm, Germany)

Break 15:00-15:15

Nicotinic receptors in circuit excitability and epilepsy (15:15-16:15)
Speaker: Daniel Bertrand, (University of Geneva, Geneva, Switzerland)

NFLE: Excessive inhibition? (16:15-17:15)
Speaker: Gregory Mathews (
Vanderbilt University, Nashville, TN, USA)



Day 2: Friday, February 12, 2010

III. Chronobiology

The human circadian rhythm (07:30-08:30)
Speaker: Charles Czeisler (Harvard, Boston, MA, USA)

How to assess circadian rhythm in humans: A review of literature (08:30-09:30)
Speaker: Wytske Hofstra (SEIN, Zwolle, The Netherlands)

Circadian rhythms: Interactions with seizures and epilepsy (09:30-10:30)
Mark Quigg (University of Virginia, Charlottesville, VA, USA)

Break (10:30-10:50)

NFLE as a paradigm for epilepsy as dynamical disease (10:50-11:50)
Speaker: John Milton (The Claremont Colleges, Claremont, CA, USA)

Seizure prediction and the circadian rhythm (11:50-12:50)
Speaker: Hitten Zaveri (Yale University, New Haven, CT, USA)

Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy (12:50-13:05)
Speaker: Paul Carney (University of Florida, Gainesville, FL, USA)

NFLE: A window/route to prediction and development of a data base (13:05-13:50)
Speaker: Ivan Osorio, (
University of Kansas, Kansas City, KS, USA)


IV. Future research directions in NFLE

Future research directions (13:50-15:00, working lunch)
Participants: All



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